By Esen Özkaya, Kurtuluş Didem Yazganoğlu
Adverse cutaneous drug reactions (ACDR) are one of the so much widespread occasions in sufferers receiving drug remedy. Cardiovascular (CV) medicinal drugs are a huge workforce of substances with power danger of constructing ACDR specifically in aged as advertising and marketing of extra new medicinal drugs and their prescription proceed to extend. even if, like with so much different medicines the precise prevalence of cutaneous negative effects from CV medicines is hard to estimate as a result of sporadic reporting. additionally, a competent designation of a undeniable drug because the reason for a definite form of response can infrequently be made. except the well known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid response from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV medications may be visible in a large spectrum extending to infrequent yet life-threatening stipulations corresponding to erythroderma, Stevens-Johnson syndrome, poisonous epidermal necrolysis or drug allergic reaction syndrome. during this complete overview, the mentioned sorts of ACDR to CV medications might be mentioned in keeping with drug type and the kind of dermatologic response with designated emphasize on cross-reactions and the position of patch checking out in diagnosis.
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The lips (Figs. 31), hands, and genitalia (especially male genitalia) are frequently involved sites. FDE on the lips might be difficult to differentiate from herpes simplex infection. Mucosal lesions are usually bullous/ erosive (Fig. 32) but they may also present with aphthous or erythematous morphology . Bullous/erosive mucosal lesions might be difficult to differentiate from pemphigus vulgaris, EM major, or SJS . Aphthous mucosal lesions should be differentiated from aphthous stomatitis, herpes simplex infection, and Behçet’s disease.
58). It usually starts within 1–3 weeks of therapy with the offending drug, with prodromal symptoms like fever, headache, malaise, and myalgia. The face, neck, trunk, and extremities including the palms and soles are usually involved. Histopathology of bullous lesions shows full-thickness epidermal necrosis with subepidermal blistering. At least one mucosal area is involved such as oral, genital, conjunctival, pharyngeal, laryngeal, or perianal, showing painful hemorrhagic bullae and erosions. The lips are typically covered with hemorrhagic crusts (Fig.
The five diagnostic criteria of SDRIFE include (1) exposure to a systemically administered drug that is not a contact allergen, first or repeated doses, (2) sharply demarcated erythema of the gluteal/perianal area and/or V-shaped erythema of the inguinal/perigenital area, (3) involvement of at least one 10 Fig. 10 Eczematous drug eruption on the back skin and the outer part of the upper extremity showing widespread erythematous, edematous, and vesicular lesions Fig. 11 Eczematous drug eruption on the flexural part of the upper extremity and on the trunk showing erythematous, edematous, and vesicular lesions 1 General Aspects of Adverse Cutaneous Drug Reactions Characteristic Features of Adverse Cutaneous Drug Reactions Fig.
Adverse Cutaneous Drug Reactions to Cardiovascular Drugs by Esen Özkaya, Kurtuluş Didem Yazganoğlu