Get Acute Exposure Guideline Levels for Selected Airborne PDF

By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

ISBN-10: 030908511X

ISBN-13: 9780309085113

ISBN-10: 0309567734

ISBN-13: 9780309567732

Record from the Subcommittee on Acute publicity guide degrees and the Committee on Toxicology from the Board on Environmental experiences and Toxicology. quantity 2. Softcover.

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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2

Sample text

Animals were exposed in a 364-L glass and stainless-steel chamber, and phosgene concentrations were estimated with a phosgene detector tube. ” Groups of six to eight rats per concentration were sacrificed 0, 30, 60, or 90 min after exposure. No percentage change of lung water (used as a measure of pulmonary edema) was observed in rats exposed to phosgene at 100 or 200 ppm and sacrificed 0 and 30 min after exposure. 7% increase in lung water. 8% after rats were exposed at 100 ppm and sacrificed 0, 30, and 60 min after exposure.

Information synthesized from this review is presented in Table 1–3. Based on observations during World War I, the 2 min LC50 value for humans was estimated to be 790 ppm (Chasis 1944). TABLE 1–2 Physical and Chemical Data Data Reference Parameter Synonyms Carbonyl chloride, carbon Lipsett et al. 1994; oxychloride, carbonic EPA 1986 dichloride, chloroformyl chloride Lipsett et al. 92 Lipsett et al. 1994 CAS registry no. 75–44–5 Lipsett et al. 1994 Physical state Gas Lipsett et al. 4 (air=1) Lipsett et al.

1990) Inhalation is the most important route of exposure for phosgene. Because of phosgene’s mild upper respiratory, eye, and skin irritancy and mildly pleasant odor, an exposed victim may not actively seek an avenue of escape before lower respiratory damage has occurred (Currie et al. 1987a; Lipsett et al. 1994). Pulmonary edema is the cause of death after a clinical latency period of ≤24 h (Franch and Hatch 1986). The chemical structure is depicted below, and the physicochemical properties of phosgene are presented in Table 1–2.

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Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2 by National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels


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